Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice
نویسندگان
چکیده
منابع مشابه
Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice
Immunoglobulins (Ig), particularly IgE, are believed to be crucially involved in the pathogenesis of asthma and, equally, in allergic models of the disease. To validate this paradigm we examined homozygous mutant C57BL/6 mice, which are B cell deficient, lacking all Ig. Mice were immunized intraperitoneally with 10 micrograms ovalbumin (OVA) plus alum, followed by daily (day 14-20) 30 min expos...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.185.5.885